CURRIE LAB

Publications

For a complete list of publications, see PubMed.

Selected Publications

Targets of histone H3 lysine 9 methyltransferases

Levinsky AJ, McEdwards G, Sethna N, Currie MA
2022, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2022.1026406

Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability

Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
2018, Nature, 10.1038/s41586-018-0398-2

2024

Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro

Harracksingh AN, Singh A, Mayorova TD, Bejoy B, Hornbeck J, Elkhatib W, McEdwards G, Gauberg J, Taha A, Islam IM, Erclik T, Currie MA, Noyes M, Senatore A
2024, Scientific Reports, 10.1038/s41598-024-70652-8

The binding of Mint/X11 PDZ domains to CaV2 calcium channels predates bilaterian animals

Harracksingh AN, Singh A, Mayorova T, Bejoy B, Hornbeck J, Elkhatib W, McEdwards G, Gauberg J, Taha ARW, Islam IM, Erclik T, Currie MA, Noyes M, Senatore A
2024, Cold Spring Harbor Laboratory - bioRxiv, 10.1101/2024.02.26.582151

Plastid ancestors lacked a complete Entner-Doudoroff pathway, limiting plants to glycolysis and the pentose phosphate pathway

Evans SE, Franks AE, Bergman ME, Sethna NS, Currie MA, Phillips MA
2024, Nature Communications, 10.1038/s41467-024-45384-y

Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation

Kailass K, Casalena D, Jenane L, McEdwards G, Auld DS, Sadovski O, Kaye EG, Hudson E, Nettleton D, Currie MA, Beharry AA
2024, Journal of Medicinal Chemistry, 10.1021/acs.jmedchem.3c01850

2023

The BAH domain: A versatile histone modification reader

Currie MA, Behrouzi R, Moazed D
2023, Chromatin Readers in Health and Disease, 10.1016/B978-0-12-823376-4.00006-9

Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa

Elkhatib W, Yanez-Guerra LA, Mayorova TD, Currie MA, Singh A, Perera M, Gauberg J, Senatore A
2023, Communications Biology, 10.1038/s42003-023-05312-0

2022

Function and phylogeny support the independent evolution of acid-sensing ion channels in the Placozoa

Elkhatib W, Yanez-Guerra L, Mayorova TD, Currie MA, Perera M, Singh A, Gauberg J, Senatore A
2022, Cold Spring Harbor Laboratory - bioRxiv, 10.1101/2022.06.28.497943

Targets of histone H3 lysine 9 methyltransferases

Levinsky AJ, McEdwards G, Sethna N, Currie MA
2022, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2022.1026406

2021

Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins

Wong SJ, Ringel AE, Yuan W, Paulo JA, Yoon H, Currie MA, Haigis MC
2021, Journal of Biological Chemistry, 10.1016/j.jbc.2021.100397

2018

Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability

Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
2018, Nature, 10.1038/s41586-018-0398-2

2017

Structural and functional characterization of the TYW3/Taw3 className of SAM-dependent methyltransferases

Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z
2017, RNA, 10.1261/rna.057943.116

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D
2017, Nature, 10.1038/nature23267

2016

Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D
2016, eLife, 10.7554/eLife.17556

2013

Small Angle X-ray Scattering Analysis ofClostridium thermocellumCellulosome N-terminal Complexes Reveals a Highly Dynamic Structure

Currie MA, Cameron K, Dias FMV, Spencer HL, Bayer EA, Fontes CMGA, Smith SP, Jia Z
2013, Journal of Biological Chemistry, 10.1074/jbc.M112.408757

Structural basis of calcineurin activation by calmodulin

Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z
2013, Cellular Signalling, 10.1016/j.cellsig.2013.08.033

2012

Scaffoldin Conformation and Dynamics Revealed by a Ternary Complex from theClostridium thermocellumCellulosome

Currie MA, Adams JJ, Faucher F, Bayer EA, Jia Z, Smith SP
2012, Journal of Biological Chemistry, 10.1074/jbc.M112.343897

2010

Insights into Higher-Order Organization of the Cellulosome Revealed by a Dissect-and-Build Approach: Crystal Structure of Interacting Clostridium thermocellum Multimodular Components

Adams JJ, Currie MA, Ali S, Bayer EA, Jia Z, Smith SP
2010, Journal of Molecular Biology, 10.1016/j.jmb.2010.01.015

Purification and crystallization of a multimodular heterotrimeric complex containing both type I and type II cohesin–dockerin interactions from the cellulosome ofClostridium thermocellum

Currie MA, Adams JJ, Ali S, Smith SP, Jia Z
2010, Acta Crystallographica Section F Structural Biology and Crystallization Communications, 10.1107/S1744309110001375

2009

Preparation and Characterization of Bacterial Protein Complexes for Structural Analysis

Matte A, Kozlov G, Trempe J, Currie MA, Burk D, Jia Z, Gehring K, Ekiel I, Berghuis AM, Cygler M
2009, , 10.1016/S1876-1623(08)76001-2

ADP-dependent 6-Phosphofructokinase fromPyrococcus horikoshiiOT3

Currie MA, Merino F, Skarina T, Wong AHY, Singer A, Brown G, Savchenko A, Caniuguir A, Guixé V, Yakunin AF, Jia Z
2009, Journal of Biological Chemistry, 10.1074/jbc.M109.012401